By John S. Bradley MD, John D. Nelson MD Emeritus, Dr. David W Kimberlin MD FAAP, Dr. John A.D. Leake MD MPH, Dr. Paul E Palumbo MD, Dr. Pablo J Sanchez MD, Dr. Jason Sauberan PharmD, Dr. William J Steinbach
This bestselling and commonplace source on pediatric antimicrobial remedy offers speedy entry to trustworthy ideas for therapy of all infectious ailments in children.
For every one sickness, the authors offer a remark to assist healthiness care prone decide on the easiest of all antimicrobial offerings. The inquiring health practitioner can instantly hyperlink to the facts for the advice within the book or cellular model. Drug descriptions disguise all antimicrobial brokers on hand at the present time and contain whole information regarding dosing regimens.
In reaction to becoming issues approximately overuse of antibiotics, the e-book comprises guidance on whilst to not prescribe antimicrobials.
Key positive aspects in nineteenth Edition!
- up to date information about the power and the extent of facts for all therapy suggestions
- New bankruptcy on antibiotic treatment for overweight youngsters
- New bankruptcy on antimicrobial prophylaxis and prevention of symptomatic an infection
- comprises therapy of parasitic infections and tropical drugs.
- up to date anti-infective drug directory, whole with formulations and dosages.
- Balanced details on safeguard, efficacy and tolerability with facts on bills and availability of substances
Read or Download 2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th Edition PDF
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Additional info for 2012-2013 Nelson's Pediatric Antimicrobial Therapy, 19th Edition
Chlamydia trachomatis68 Azithromycin PO, IV q24h for 5 days or erythromycin ethylsuccinate PO for 14 days (AII) Association of erythromycin and pyloric stenosis in young infants – Mycoplasma hominis69–72 Clindamycin PO, IV for 10 days (organisms are resistant to macrolides) Pathogenic role in pneumonia not well defined and clinical efficacy unknown; no association with bronchopulmonary dysplasia (BIII). – Pertussis73 Azithromycin 10 mg/kg PO, IV q24h for 5 days, or erythromycin ethylsuccinate PO for 14 days (AII) Association of erythromycin and pyloric stenosis in young infants; may also occur with azithromycin Alternatives for >1 mo of age, clarithromycin for 7 days, and for >2 mo of age, TMP/SMX for 14 days – P aeruginosa74 Ceftazidime IV, IM AND tobramycin IV, IM for ≥10–14 days (AIII) Alternatives: cefepime or meropenem, OR pip/tazo AND tobramycin Comments Pulmonary infections 24 — Chapter 5.
Antimicrobial Dosages for Neonates (cont) C. 5 mg/kg q24h (see Chapter 11). b Desired serum concentrations: 20–30 mg/L (peak), <5 mg/L (trough). c Desired serum concentrations: 5–10 mg/L (peak), <2 mg/L (trough). 6 15 q48h Up through 60 days of age. Can consider 30–40 mg/kg/day div q6-8h if >60 days of age (see Chapter 11). Desired serum concentrations: 20–40 mg/L (peak), <10–15 mg/L (trough); for MRSA infections, trough 15–20 mg/L. b 2012–2013 Nelson’s Pediatric Antimicrobial Therapy — 35 D. VANCOMYCIN 36 — Chapter 5.
In general, the neonatal exposure is well tolerated. While maternal treatment with sulfa-containing antibiotics should be approached with caution in the breastfed infant who is jaundiced or ill, no neonatal symptoms have been associated with maternal treatment with amoxicillin, cefazolin, cefotaxime, ceftazidime, ceftriaxone, ciprofloxacin, clindamycin, erythromycin, ethambutol, fluconazole, gentamicin, isoniazid, and rifampin (used for <3 weeks). 94 37 6. Antimicrobial Therapy According to Clinical Syndromes NOTES • This chapter should be considered a rough guideline for a typical patient.