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By Victor R. Preedy

Aging: Oxidative rigidity and nutritional Antioxidants bridges the trans-disciplinary divide and covers in one quantity the technology of oxidative pressure in getting older and the doubtless healing use of ordinary antioxidants within the vitamin or foodstuff matrix. The methods in the technological know-how of oxidative pressure are defined in live performance with different strategies, corresponding to apoptosis, cellphone signaling, and receptor mediated responses. This method acknowledges that illnesses are usually multifactorial, and oxidative rigidity is a unmarried part of this.

Gerontologists, geriatricians, nutritionists, and dieticians are separated by means of divergent abilities disciplines that must be bridged so that it will enhance preventative in addition to remedy ideas. whereas gerontologists and geriatricians may possibly examine the underlying approaches of getting older, they're much less more likely to be acquainted with the technology of food and dietetics. nevertheless, nutritionists and dietitians are much less conversant with the specified medical history and technology of gerontology. This e-book addresses this hole and brings every one of those disciplines to undergo at the procedures inherent within the oxidative pressure of getting older.

  • Nutritionists can observe info concerning mitochondrial oxidative rigidity in a single affliction to diet-related thoughts in one other unrelated ailment
  • Dietitians can prescribe new meals or diets containing anti-oxidants for stipulations immune to traditional pharmacological remedies
  • Dietitians, after studying concerning the uncomplicated biology of oxidative rigidity, could be in a position to recommend new remedies to their multidisciplinary teams
  • Nutritionists and dietitians will achieve an realizing of mobile signaling and be capable to recommend new preventative or healing ideas with anti-oxidant wealthy foods

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Extra resources for Aging. Oxidative Stress and Dietary Antioxidants

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AMPK regulates cellular energy metabolism by mitophagy and mitogenesis: destruction of defective mitochondria and activation of mitochondrial biogenesis, respectively. 35 The Cardiovascular System and AMPK In humans, hereditary syndromes due to AMPK mutations have a pathologic component in cardiovascular decline. AMPK mutations cause hypertrophic cardiomyopathy and ventricular pre-excitation. 36,37 1. OXIDATIVE STRESS AND AGING 32 3. CARDIOVASCULAR DISEASE IN AGING AND THE ROLE OF OXIDATIVE STRESS Oxidative Stress and AMPK AMPK is a target of pharmaceutical regulation for its role in defense against mitochondrial oxidative stress.

G. host and pathogen defense and alcohol metabolism). g. in obesity or insulin resistance). 55 A significant role for catalase has also been demonstrated in oxidative stress-induced cardiac remodeling. Mice with cardiac-specific Gq-α subunit overexpression provide a model for structural changes in the cardiovascular system. In their system, oxidative stress also increases at a faster than normal rate. The increase in oxidative stress causes dilated cardiomyopathy, which progresses to heart failure.

This was investigated by inducing mitochondrial oxidative stress through inhibition of mitochondrial complex II with 3-nitropropionic acid (3-NPA) treatment. The activator protein 1 (AP-1) transcription factor, which regulates transcriptional responses to numerous stimuli, contains c-Jun family proteins. Phosphorylation of Ser63 and Ser73 residues on the c-Jun protein is necessary to mediate apoptotic and/or proliferative responses to oxidative stress. In the dwarf mouse, after generation of mitochondrial oxidative stress by 3-NPA treatment, there is a lack of c-Jun Ser63 phosphorylation.

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