By Steven E Ed Hyman
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Extra info for Annual Review of Neuroscience 2008
2003). However, in young rats tLTP can be rescued by replacing the single postsynaptic spike with a burst or by adding GABAA antagonists, suggesting that the change in tLTP threshold might be due to a developmental enhancement of inhibition in this circuit. PLASTICITY OF NEURONAL EXCITABILITY AND SYNAPTIC INTEGRATION Information processing by neuronal networks depends not only on the connectivity between neurons, but also on the intrinsic conductances in each neuron that determine its excitability and synaptic integration.
Org • Spike Timing–Dependent Plasticity 29 Annu. Rev. Neurosci. 31:25-46. org by Ball State University on 01/08/09. For personal use only. for regulating experience-dependent developmental plasticity (Hensch 2005). Although the strength of excitatory synapses can be modiﬁed through STDP, an important question is whether and how correlated pre- and postsynaptic activity affects inhibitory circuits. Inhibition in a network depends on both the excitatory synapses onto inhibitory neurons and the inhibitory synapses themselves.
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