Download Background Lesions in Laboratory Animals. A Color Atlas by Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath PDF

By Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath

Background Lesions in Laboratory Animals might be a useful reduction to pathologists wanting to acknowledge heritage and incidental lesions whereas studying slides taken from laboratory animals in acute and persistent toxicity reports, or whereas studying unique species in a diagnostic laboratory. It offers transparent descriptions and illustrations of the vast majority of historical past lesions prone to be encountered. a few of the lesions lined are strange and will be improper for treatment-related findings in preclinical toxicity studies.

The Atlas has been ready with contributions from skilled toxicological pathologists who're experts in all the laboratory animal species lined and who've released largely in those areas.

  • over six hundred high-definition, gold standard colour pictures of historical past lesions present in rats, mice, canine, minipigs, non-human primates, hamsters, guinea pigs and rabbits
  • a separate bankruptcy on lesions within the reproductive structures of all laboratory animals written through Dr Dianne Creasy, a global professional on testicular lesions in laboratory animals
  • a bankruptcy on universal artifacts which may be saw in histological glass slides
  • extensive references to every lesion described
  • aging lesions encountered in all laboratory animal species, really in rats in mice that are used for carcinogenicity studies

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Extra info for Background Lesions in Laboratory Animals. A Color Atlas

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17) (Colby et al 2007). 17 Dilated subpleural lymphatics. ×100. 14 Fibrosing alveolitis at higher magnification characterized by fibrosis of the alveolar septae with a hyperplastic epithelial lining with or without an associated inflammatory reaction. ×100.

200. e. blood-filled spaces, may occur in the islets of aging rats (Frith et al 2000a). Pancreatic hepatocytes are occasionally observed in the periphery around an islet in the pancreas and are thought to derive from pancreatic acinar cells (Frith et al 2000a). Peri-insular halos (juxtainsular cells) consist of large, acinar cells adjacent to the islets with enlarged nuclei and granular, hypereosinophilic cytoplasm due to an increase in zymogen granules (Kramer & Tan 1968). The cause is thought to be due to the greater concentrations of insulin in the cells immediately adjacent to the islets (Kramer & Tan 1968) (Fig.

Here, the pars intermedia and the pars nervosa of the pituitary may contain focal, unremarkable, glandular structures which do not display neoplastic transformation (Fig. 95). The epithelium lining the glandular structures as well as the cyst is largely cuboidal and the cyst lining is ciliated (Frith et al 2000a). 96 Angiectasis in the rat pituitary. ×40. 94 Pituitary cyst in the pars intermedia in the rat. ×200. 97 Focal hyperplasia of the pars distalis of the rat pituitary. ×100. 95 Rathke’s pouch remnants in the rat pituitary gland.

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