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By Daniela Galimberti

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San Antonio, TX: Psychological Corporation. , Payami, H. A. (1997). Cognitive markers preceding Alzheimer’s dementia in the healthy oldest old. Journal of the American Geriatrics Society, 45, 584–589. [26] Wechsler, D. (1987). The Wechsler Memory Scale-Revised Manual. New York: Psychological Corporation. , Horwitz, M. & Ritter, W. (1969). Patterns of behavioral deficit associated with visual spatial neglect. Cortex, 5, 242-263. 26 A. Monti, B. Poletti and S. C. (1973). Guide to using the Coloured Progressive Matrices.

2003). , 1999). , 2001). , 1994). , 1992). , 1992). 42 Valentina Garibotto and Daniela Perani In particular, a prospective study of FDG PET has addressed the issue of progression rate of AD, and found that impairment of glucose metabolism in temporo-parietal or frontal association areas measured with PET is significantly associated with dementia severity, clinical classification as possible vs. , 1999). The correlation between initial metabolic ratio and subsequent decline of MMSE score during follow-up is particularly evident in mildly affected patients.

3. , brain tumours or epidural haematomas. Recently, however, the potential of neuroimaging, not only to improve the accuracy of the clinical diagnosis of AD, but also to monitor disease progression and treatment effects, has been increasingly recognized. Imaging might be particularly helpful in providing a marker for disease in early and preclinical phases of AD. , 2004). Power analyses showed that neuroimaging as outcome markers in treatment trials would allow for substantially smaller patient populations and shorter observation times than cognitive or clinical outcome measures currently do.

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