Download Brain Disease: therapeutic strategies and repair by Oded Abramsky, D. Alastair S. Compston, Ariel Miller, Gerard PDF

By Oded Abramsky, D. Alastair S. Compston, Ariel Miller, Gerard Said

During this quantity, best scientists evaluation new findings on how the significant frightened procedure (CNS) responds to damage. mind sickness addresses the mechanisms of CNS issues, comparable to a number of sclerosis, Alzheimer's ailment, stroke and irritating mind harm. realization is targeted at the function of genetic and environmental elements, pathophysiology of immune-mediated mind harm, blood-brain barrier eruption and mind edema, apoptotic mechanisms and the matrix metalloproteinases. different subject matters contain fix mechanisms, gene treatment and using stem cells for CNS remyelination. The textual content is key for practising neurologists, neurosurgeons, geriatricians and scholars in these fields.

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36 Quinolinic acid is known to be produced by macrophages and may be one of the more important neurotoxins. Its neurotoxicity can be demonstrated not only under acute conditions, but also with chronic exposure at relatively low concentrations, which may be more relevant for a chronic disease. Activated macrophages and microglia generate reactive oxygen species (ROS) that may also induce injury of myelin, oligodendrocytes and neurons. 37 Nitric oxide (NO) has been implicated in neurotoxicity in many neurological diseases.

Wilt SC, Milward E, Zhou JM et al. In vitro evidence for a dual role of tumor necrosis factor alpha in human immunodeficiency virus type 1 encephalopathy. Ann Neurol 1995; 37: 381–394. 26. Declercq W, Denecker G, Fiers W, Vandenabeele P. Cooperation of both TNF receptors in inducing apoptosis: involvement of the TNF receptor-associated factor binding domain of the TNF receptor 75. J Immunol 1998; 161: 390–399. 27. D’Souza S, Alinauskas K, McCrea E, Goodyer C, Antel JP. Differential susceptibility of human CNS-derived cell populations to TNF-dependent and independent immune-mediated injury.

30. Ladiwala U, Li H, Antel JP, Nalbantaglu J. p53 induction by tumor necrosis factor alpha and involvement of p53 in cell death of human oligodendrocytes. J Neurochem 1999; 73: 605–611. MICROGLIA AND BRAIN MACROPHAGES 31. Pouly S, Becher B, Blain M, Antel JP. Interferon gamma modulates human oligodendrocyte susceptibility to Fas-mediated apoptosis. J Neuropathol Exp Neurol 2000; 59: 280–286. 32. Bachwich PR, Censue SW, Larrick JW, Kunkel SL. Tumor necrosis factor stimulates interleukin-1 and prostaglandin E2 production in resting macrophages.

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