By Oded Abramsky, D. Alastair S. Compston, Ariel Miller, Gerard Said
During this quantity, best scientists evaluation new findings on how the significant frightened procedure (CNS) responds to damage. mind sickness addresses the mechanisms of CNS issues, comparable to a number of sclerosis, Alzheimer's ailment, stroke and irritating mind harm. realization is targeted at the function of genetic and environmental elements, pathophysiology of immune-mediated mind harm, blood-brain barrier eruption and mind edema, apoptotic mechanisms and the matrix metalloproteinases. different subject matters contain fix mechanisms, gene treatment and using stem cells for CNS remyelination. The textual content is key for practising neurologists, neurosurgeons, geriatricians and scholars in these fields.
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Additional info for Brain Disease: therapeutic strategies and repair
36 Quinolinic acid is known to be produced by macrophages and may be one of the more important neurotoxins. Its neurotoxicity can be demonstrated not only under acute conditions, but also with chronic exposure at relatively low concentrations, which may be more relevant for a chronic disease. Activated macrophages and microglia generate reactive oxygen species (ROS) that may also induce injury of myelin, oligodendrocytes and neurons. 37 Nitric oxide (NO) has been implicated in neurotoxicity in many neurological diseases.
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