Download Bursting: the genesis of rhythm in the nervous system by Stephen Coombes, Paul C. Bressloff PDF

By Stephen Coombes, Paul C. Bressloff

Neurons within the mind converse with one another by way of transmitting sequences of electric spikes or motion potentials. one of many significant demanding situations in neuroscience is to appreciate the fundamental physiological mechanisms underlying the advanced spatiotemporal styles of spiking task saw in the course of basic mind functioning, and to figure out the origins of pathological dynamical states comparable to epileptic seizures and Parkinsonian tremors. A moment significant problem is to appreciate how the styles of spiking task offer a substrate for the encoding and transmission of data, that's, how do neurons compute with spikes? it truly is most likely that a tremendous portion of either the dynamical and computational houses of neurons is they can express bursting, that's a comparatively sluggish rhythmic alternation among an lively part of fast spiking and a quiescent part with out spiking. This e-book presents an in depth assessment of the present cutting-edge within the mathematical and computational modeling of bursting, with contributions from some of the prime researchers within the box.

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They also point out that "whereas other VTA and SN neurons col- 36 Cortical Memory Functions lateralize to prefrontal and suprarhinaIlperirhinal/piriform cortices ... " These features may be extremely important; specifically, they suggest that "motivational" input to entorhinalis is from the basal dopaminergic system, without an extrapyramidal component (from SN), and without diffuse distribution of the same input to other areas (via collaterals). This may, in other words, be an arrangement that acts, at the level of subcortico-cortical input, to separate inputs conducive to the "declarative" (or sensory-related) type of memory formation from those conducive to the more frontally-represented "procedural" (or action-related) types of memory.

According to that model, the flow of information across the cortex, from the prime receiving into the association areas, and finally to entorhinalis, entails increasing generalization of the data relayed. Since, at the several stages in this throughput system, the data also become associatively cross-linked (Fig. 2-2, above), they are more holistic. That is, because each of the cross-linked components is itself generalized, the linkage between them amounts to a higher order generalization, with a proportionately broader base in specific referents represented at earlier stages in the relay.

1990; in vivo, rat). A distinguishing feature of sensitization is that, being primarily presynaptic, it tends to generalize-that is, to produce corresponding changes in the output of the units to which it projects (whose numbers, in a system such as neocortex, can be very large). Kandel and Schwartz (loc. ) describe sensitization as resulting, behaviorally, in an animal that tends "to respond vigorously to a variety of previously neutral or indifferent stimuli after it has been exposed to a potentially threatening or noxious stimulus.

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